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作者发现地高辛加用乙胺碘呋酮治疗时会出现地高辛中毒,为此而采用放射免疫法,测定了7例地高辛加乙胺碘呋酮(200mg 每日3次)治疗难治性心律失常病人的血浆地高辛浓度.所有病人有发作性或持续性的心房纤颤,其中3例曾有其它室上性心律失常。结果加用乙胺碘呋酮后,血浆地高辛浓度增加,平均为69%,4例发生地高辛中毒症状。单独用地高辛治疗的6例室上性心律失常对照病人,其血浆地高辛浓度没有增加。仅用乙胺碘呋酮的4例病人,经放射免疫法测定血浆中无地高辛.说明乙胺碘呋酮
The authors found that digoxin plus dighetamine in the treatment of digoxin poisoning, for this purpose by radioimmunoassay, measured in 7 cases of digoxin plus amiodarone (200mg 3 times a day) treatment Plasma digoxin concentrations in patients with refractory arrhythmias All patients had episodic or persistent atrial fibrillation and 3 had other supraventricular arrhythmias. Results After adding amiodarone, plasma digoxin concentration increased, with an average of 69%, 4 cases of symptoms of digoxin poisoning. 6 cases of digoxin alone treatment of supraventricular arrhythmia control patients, the plasma digoxin concentration did not increase. Only 4 cases of amiodarone in patients with plasma radioimmunoassay determination of digoxin, indicating that amiodarone