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本文报道了用阿托品及神经节苷脂(Ga(?)gliosidi)治疗急性溴氰菊酯中毒大鼠的效果。结果表明,给大鼠以5mg/kg剂量溴氰菊酯静脉染毒未经治疗者均出现流涎、兴奋、舞蹈、扭动等典型的急性溴氰菊酯中毒症状,全部于36分钟内死亡。用同等剂量染毒的动物如单以阿托品2.4mg/kg或同时加神经节苷酯50mg/kg治疗的动物有半数存活,死亡者延长死亡时间,以神经节苷脂30mg/kg治疗的动物亦有三分之一存活,死亡动物的死亡时间也有延长。若以阿托品8mg/kg治疗亦稍能延长动物死亡时间,但不减少死亡数。阿托品对大鼠溴氰菊酯中毒所致的运动症状无明显效果,但对流涎有抑制作用。阿托品与神经节苷酯无协同作用。
This article reports the efficacy of atropine and gangliosides (Ga (?) Gliosidi) in the treatment of acute deltamethrin poisoning in rats. The results showed that typical acute deltamethrin intoxication symptoms such as drooling, excitement, dances and writhings were all occurred in rats treated with 5 mg / kg dose of deltamethrin intravenously, all of which died within 36 minutes. Animals exposed to the same dose such as atropine 2.4 mg / kg alone or concurrently with ganglioside 50 mg / kg had half survived, those who died prolonged death, animals treated with ganglioside 30 mg / kg One-third survived and deaths of dead animals also increased. If atropine 8mg / kg treatment also slightly prolonged animal deaths, but does not reduce the number of deaths. Atropine on the deltamethrin poisoning caused by exercise symptoms without significant effect, but the salivary inhibition. Atropine and ganglioside no synergistic effect.