经皮肝穿刺活检是一种侵入性诊断,对人体有损害。测定血清中的某些化学成分来评估肝病损、特别是肝纤维化是可行的。胶原和基膜代谢标记物——血清前胶原Ⅲ肽(PⅢP)与各种肝病纤维化有关,由凝血酶原时间(P),γ-谷酰转肽酶(G)和载脂蛋白Al(a)构成的PGA生物学指数也能敏感地反映酒精性肝纤维化的活动度。本文作者比较了血清PⅢP和PGA指数在评估各种肝纤维化中的作用。 Percutaneous liver biopsy is an invasive diagnosis of human damage. It is feasible to measure certain chemical components in serum to assess liver damage, especially liver fibrosis. Collagen and the basement membrane metabolic markers - serum procollagen III peptide (P Ⅲ P) and a variety of liver fibrosis related by the prothrombin time (P), γ-glutamyl transpeptidase (G) and apolipoprotein Al ( a) The composition of the PGA biological index can also sensitively reflect the activity of alcoholic liver fibrosis. The authors compared the role of serum PIIIP and PGA indices in assessing various hepatic fibrosis.