目的　探讨准分子激光原位角膜磨镶术(LASIK)后角膜融解的发病原因、临床表现及相关因素,为临床预防和治疗提供依据。方法　对LASIK术后角膜融解患者11例(12只眼)进行临床分析,观察并记录临床表现;进行全身系统检查,尤其免疫学检查,明确诊断;采用局部给药配合全身疾病治疗方案,并观察疗效和转归。结果　10例患者单眼发病,仅1例患者双眼发病。角膜融解部位为角膜瓣边缘,以下方和鼻侧多见; 8只眼(67% )术中角膜上皮剥脱、角膜瓣过薄或术后角膜上皮水肿、角膜上皮植入。6例(55% )患者合并全身疾患,其中甲状腺炎1例(1只眼),系统性红斑狼疮2例(2只眼),干燥综合征2例(2只眼),类风湿性关节炎1例(1只眼);有浅层巩膜炎病史1例(1只眼),皮肤出现湿疹、红斑1例(1只眼),角膜瓣下异物1例(1只眼);无其他疾病者2例( 3只眼)。经眼局部使用环孢霉素A、糖皮质激素、抗生素及角膜保护剂配合全身疾病治疗,患者全部治愈;病程23~45d,平均30 3d;角膜病灶处残留不同程度薄翳或斑翳;角膜散光度数≥1 00D4只眼( 1 00~5 50D),实际矫正视力低于预期矫正视力2行5只眼, 1行2只眼,无下降5只眼。结论　角膜融解是一种与全身性疾病有关的非感染性角膜疾病,LASIK可能为诱发因素。LASIK术前详细的全身系统性检查和术中规范的手术操作对减少角 Objective To investigate the etiology, clinical manifestations and related factors of corneal thalassemia after laser in situ keratomileusis (LASIK), and to provide basis for clinical prevention and treatment. Methods Eleven patients (12 eyes) with corneal lysis after LASIK were analyzed clinically, and their clinical manifestations were observed and recorded. All the patients were diagnosed by systemic examination, especially by immunological examination, and diagnosed by definite diagnosis. The local administration combined with systemic disease treatment and observation Efficacy and outcome. Results 10 patients with monocular disease, only 1 patient binocular disease. Corneal melting site for the flap edge, the following side and nasal more common; 8 eyes (67%) intraoperative corneal epithelial exfoliation, corneal flap is too thin or postoperative corneal epithelial edema, corneal epithelial implantation. Six patients (55%) had systemic conditions including one case of thyroiditis (1 eye), 2 cases of systemic lupus erythematosus (2 eyes), 2 cases of Sjogren’s syndrome (2 eyes), rheumatoid arthritis 1 case (1 eye); 1 case of history of superficial scleritis (1 eye), skin eczema, 1 case of erythema (1 eye) and 1 case of corneal foreign body (1 eye); no other diseases 2 cases (3 eyes). The topical eye use cyclosporin A, glucocorticoids, antibiotics and corneal protective agent with the treatment of systemic diseases, all patients were cured; duration of 23 ~ 45d, an average of 30 3d; corneal lesions left at varying degrees of thin 翳 or canthus; cornea Astigmatism≥1 00D4 eyes (100 ~ 5 50D), the actual corrected visual acuity was lower than expected vision correction 2 lines 5 eyes, 1 line 2 eyes, no decrease 5 eyes. Conclusion Corneal melting is a non-infectious corneal disease associated with systemic diseases. LASIK may be a predisposing factor. LASIK preoperative detailed systemic systematic examination and intraoperative normative surgical procedures to reduce the angle