目的通过检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者经持续气道正压通气治疗前后的血清瘦素水平,以探究持续气道正压通气治疗对OSAHS患者血清瘦素的影响.方法选取30例OSAHS且行持续气道正压通气治疗的患者为观察组,32例同期健康体检患者为对照组.测定观察组患者持续正压通气治疗前后的血清瘦素水平,并与对照组进行比较.结果OSAHS患者经持续气道正压通气治疗后,且治疗后血清瘦素含量较治疗前显著下降,差异具有统计学意义(P〈0.05).结论持续气道正压通气治疗可有效降低血清瘦素水平. “,”Objective To provide reference for clinical treatment by exploring effect of continuous positive airway pressure on the serum leptin levels of patients with obstructive sleep apnea hypopnea syndrome (OSAHS), we detected the levels of patients with OSAHS. Methods Thirty patients with OSAHS and then treated with continuous positive airway pressure treatment were selected into the observation group, 32 healthy cases in the same period were sdected as control group. Levels of serum leptin were detected between observation group and control group. Results After treated with continuous positive airway pressure, compared with control group, the serum leptin levels were significantly decreased (P 〈 0.05). Conclusion Continuous positive airway pressure treatment can effectively reduce serum leptin levels and slow down the deterioration of OSAHS patients