论文部分内容阅读
棒酸(clavulanic acid)是从带棒链霉菌分离得到的一个新的β-内酰胺酶抑制剂。当它和其他β-内酰胺抗生素,尤其是和羟氨苄青霉素联合应用时,呈现显著的协同抗菌作用。作者联合应用棒酸和羟氨苄青霉素成功的治疗了三例产生β-内酰胺酶的卡他奈瑟氏菌引起的呼吸系统感染。作者报道的三例病人均为退休的患有矽肺病的煤矿工人,具有慢性支气管急性加重的临床表现,其临床特征为:咳脓性痰、咳嗽加剧、呼吸困难及发热。作者通过气管穿刺分离致病菌。用捧酸和羟氨苄青霉素的复合制剂——BRL25000(每片含羟氨苄青霉素25Cmg和棒酸
Clavulanic acid is a new β-lactamase inhibitor isolated from Streptomyces clavuligerus. When it is used in combination with other [beta] -lactam antibiotics, especially amoxicillin, it exhibits a significant synergistic antibacterial effect. The authors successfully treated three cases of N. catarrhalis-producing respiratory infections with clavulanic acid and amoxicillin. The authors reported that all three patients were retired miners with silicosis who had clinical manifestations of acute exacerbation of chronic bronchitis. Their clinical features were cough purulent sputum, increased coughing, dyspnea and fever. The authors isolated the pathogen by tracheal puncture. A combination formulation of acid and amoxicillin - BRL25000 (each containing ampicillin 25Cmg and clavulanic acid