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目的探讨2型糖尿病患者低血糖,特别是复发性低血糖与认知功能的关系,分析影响认知功能的因素。方法对133例入选患者行蒙特利尔认知评估量表评分后,分为认知功能正常组(A,≥26分)31人,合并认知功能障碍组(B,<26分)102人。用单因素分析比较组间年龄、病程、教育年限、低血糖程度、高血压、BMI、糖尿病并发症、胆固醇、甘油三酯等指标的差异;用logistic回归分析主要影响因素。结果与认知功能障碍组比较,认知功能正常组年龄较小、低血糖发生频率低、糖尿病病程短、并发症比例低、血脂和BMI指数低,平均教育年限更多。结论低血糖发生频率、糖尿病并发症和病程、年龄、BMI、胆固醇和甘油三酯是认知功能障碍的危险因素,教育年限是认知功能的保护因素。其中低血糖发生频率和糖尿病并发症,对患者认知功能的影响最大。
Objective To investigate the relationship between hypoglycemia, especially recurrent hypoglycemia and cognitive function in type 2 diabetic patients and to analyze the factors that affect cognitive function. Methods A total of 133 patients were enrolled in the Montreal Cognitive Assessment Scale, and then divided into cognitive function group (A, ≥26 points), 31 patients, and cognitive impairment group (B, <26 points). Univariate analysis was used to compare the differences in the age, course of disease, education period, degree of hypoglycemia, hypertension, BMI, complications of diabetes, cholesterol, triglyceride and other indicators. The main influencing factors were analyzed by logistic regression. Results Compared with cognitive dysfunction group, patients with normal cognitive function had younger age, lower frequency of hypoglycemia, shorter course of diabetes, lower complication rate, lower lipids and BMI index, and more average education years. Conclusions The frequency of hypoglycemia, diabetic complications and course of disease, age, BMI, cholesterol and triglyceride are risk factors of cognitive impairment. The number of years of education is the protective factor of cognitive function. Among them, the incidence of hypoglycemia and diabetic complications have the greatest impact on patients’ cognitive function.