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目的观察常规3+7方案诱导急性髓系白血病失败后再应用CAG方案的治疗效果。方法对15例经过3+7一线诱导方案失败后的AML患者应用CAG方案化疗(阿糖胞苷10mg/m2,每12h一次,第1～14天、阿克拉霉素10～14mg/m2,1/d,第1～4天、粒细胞集落刺激因子300μg/d,1次/d,第1～14天),监测化疗前后患者的临床表现、血象及骨髓象等变化情况。结果 15例患者再应用CAG方案诱导缓解化疗中有10例获得缓解,5例未缓解,总缓解率为66.7%。结论常规3+7方案诱导急性髓系白血病失败后再应用CAG方案是一种有效的治疗方法 ,使其缓解率明显提高,是常规诱导化疗失败后挽救化疗的新的重要方向,值得临床进一步应用研究。
Objective To observe the curative effect of CAG regimen after failure of conventional 3 + 7 regimen in inducing acute myeloid leukemia. Methods Fifteen patients with AML who failed the 3 + 7 first-line induction regimen were treated with CAG regimen (cytarabine 10 mg / m2, once every 12 hours, days 1-14, aflatoxin 10-14 mg / m2, / d on day 1 to day 4, granulocyte colony-stimulating factor 300 μg / d, once / d, days 1 to 14). The changes of clinical manifestations, hemogram and bone marrow of patients before and after chemotherapy were monitored. Results Fifteen patients underwent remission with CAG regimen in 10 cases, and 5 cases did not. The overall response rate was 66.7%. Conclusion The conventional C + + regimen after the failure of conventional 3 + 7 regimen to induce acute myeloid leukemia is an effective treatment and its remission rate is significantly improved, which is a new important direction for salvage chemotherapy after the failure of conventional induction chemotherapy. It is worth further clinical application the study.