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亚急性硬化性全脑炎(SSPE)据认为是由类麻疹病毒所引起.症状始于儿童期,有人格变化、痴呆和肌阵挛发作.精神和运动进行性障碍,于数月或数年后死亡.病程可有波动,但长期自然缓解罕见.1974年应用Isoprinosine后已有数例缓解的报告.本文报告15例连续病例Isoprinosine治疗的结果.全部病人符合下列标准(1)学龄儿童或青年进行性痴呆;(2)有时有周期性肌阵挛;(3)有时脑电图有周期性改变;(4)脑脊液及血中麻疹病毒滴定度增加;和(5)脑脊液IgG含量增加(脑脊液IgG>脑脊液白蛋白的25%).药物剂量每日100毫克/公斤,每日分五次服用.发病年龄是8.5-12岁.大多数病人在药物治疗开始时已是Jabbour分级2级晚期,不能行走,高度
Subacute Sclerosing Encephalitis (SSPE) is thought to be caused by the measles virus. Symptoms start in childhood with personality changes, dementia, and myoclonic seizures. Mental and motor impairment occurs in months or years After the course of the disease there may be fluctuations, but long-term natural remission rarely seen in 1974 after the application of Isoprinosine has been reported in several cases.This article reports 15 consecutive cases of Isoprinosine treatment results.All the patients meet the following criteria (1) school-age children or young people Dementia; (2) periodic myoclonus; (3) periodic EEG changes; (4) increased titer of measles virus in cerebrospinal fluid and blood; and (5) increased IgG content in cerebrospinal fluid > 25% of cerebrospinal fluid albumin.) The dose of the drug is 100 mg / kg daily and is taken in five daily doses, with a mean age of onset of 8.5-12 years. Most patients are already Jabbour grade 2 late at the start of medication and can not Walking, height