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细胞毒作用是机体防御单纯疱疹病毒(HSV)等病毒感染的重要机制。HSV感染的细胞可被细胞毒淋巴细胞及NK细胞杀伤。许多因素,包括妊娠本身及紧张等都可能消弱细胞毒细胞的活性。一些廿烷类物质对细胞毒性有免疫调节作用。一般认为,环氧合酶产物具免疫抑制作用,脂氧合酶产物为免疫促进物。由于孕期伴有廿烷类代谢的显著改变,人们认为这或许会改变母体的免疫功能,并试图通过消除免疫抑制的影响来加强细胞毒作用。为研究妊娠、细胞毒作用及HSV感染三者间的关系,作者以鼠模型研究母体孕期与非孕期对HSV感染的细胞毒反应有无差异;在抑制环氧合酶及脂氧合酶代谢途径后,其代谢产物对细胞毒作用的影响;
Cytotoxicity is an important mechanism of the body’s defense against viral infections such as herpes simplex virus (HSV). HSV-infected cells can be killed by cytotoxic lymphocytes and NK cells. Many factors, including pregnancy itself and stress, may weaken the cytotoxic activity of cells. Some eicosanoids have immunomodulatory effects on cytotoxicity. It is generally believed that the cyclooxygenase product has an immunosuppressive effect and the lipoxygenase product is an immunostimulant. Because of significant changes in the metabolism of the alkanes during pregnancy, it is thought that this might change the immune function of the mother and try to enhance the cytotoxic effect by eliminating the effects of immunosuppression. In order to study the relationship between pregnancy, cytotoxicity and HSV infection, the authors used a mouse model to study whether there was any difference in the cytotoxic response to HSV infection between pregnant and non-pregnant women. In inhibiting the metabolism of cyclooxygenase and lipoxygenase After its metabolites on the cytotoxic effect;