论文部分内容阅读
目的 :探讨耐甲氧西林凝固酶阴性葡萄球菌 (MRCNS)在新生儿败血症中的分布、临床特征及耐药性特点。方法 :应用全自动血培养系统 (BACTE/ 90 5 0 )、ATB细菌鉴定仪 ,从 80例新生儿血培养阳性瓶中分离出 4 0株 MRCNS。应用 ATB药敏系统 ,测定了青霉素等 17种抗生素的耐药性。结果 : 80株细菌中 ,分离出 4 0株 MRCNS(占 5 0 % ) ,其中溶血葡萄球菌 17株 (42 .5 % )居首位 ,表皮葡萄球菌 15株(37.5 % ) ,其他葡萄球菌 8株 (2 0 % )。药敏结果显示多重耐药。结论 :凝固酶阴性葡萄球菌 (CNS)已成为小儿血培养的第一位检出菌 ,主要为溶血葡萄球菌和表皮葡萄球菌 ,MRCNS占主导地位 (达 5 0 %左右 ) ,成为新生儿病房院内感染的主要致病菌。药敏结果显示 MRCNS呈多重耐药 ,万古霉素及其他糖肽类抗生素是治疗 MRCNS感染的首选药物。MRCNS在新生儿病房造成院内感染的危害性以及耐药性应引起广泛关注
Objective: To investigate the distribution, clinical characteristics and drug resistance of methicillin-resistant coagulase-negative staphylococci (MRCNS) in neonatal sepsis. Methods: 40 MRCNS strains were isolated from 80 neonatal blood culture positive bottles by using automatic blood culture system (BACTE / 90 50) and ATB bacteria identification instrument. ATB drug-sensitive system was used to determine the antibiotic resistance of 17 antibiotics such as penicillin. Results: Of the 80 strains of bacteria, 40 strains of MRCNS were isolated (50%), of which 17 strains (42.5%) were predominant in Staphylococcus aureus, 15 (37.5%) were Staphylococcus epidermidis and other staphylococci Strain (20%). Drug susceptibility results show multiple drug resistance. CONCLUSIONS: Coagulase-negative staphylococci (CNS) have become the first detectable bacteria in pediatric blood cultures, mainly Staphylococcus haemolyticus and Staphylococcus epidermidis, and MRCNS predominates (up to 50%), becoming a newborn ward hospital The main pathogen of infection. MRSA showed multi-drug resistance results, vancomycin and other glycopeptide antibiotics is the treatment of MRCNS drug of choice. MRCNS neonatal ward caused nosocomial infections and drug resistance should cause widespread concern