目的探讨皮下脂膜炎样T细胞淋巴瘤(SPTCL)的临床和组织学特征。方法对8例SPTCL的临床资料、组织形态学观察、免疫组织标记等进行回顾性分析。结果临床多表现为皮下结节,下肢多见,可伴高热、消瘦等,病程进展快,大多预后较差。组织学表现为肿瘤在皮下脂肪内呈脂膜炎样浸润,细胞大小不一,均表达T细胞标志。结论SPTCL有其独特的临床表现及病理特点,多数预后差。 Objective To investigate the clinical and histological features of subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Methods The clinical data of 8 cases of SPTCL, histomorphological observation and immunohistological markers were retrospectively analyzed. Results The clinical manifestations of subcutaneous nodules, lower extremities more common, may be associated with fever, weight loss, etc., the course of progress is fast, most of the prognosis is poor. Histology showed that the tumor in the subcutaneous fat in lipid-like infiltration, cell size, all expressed T cell markers. Conclusion SPTCL has its own unique clinical and pathological features, most of the prognosis is poor.