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3-氯丙二醇具有抗生育的性能,选择地作用于副睾,不影响大鼠的交配能力,能很快地造成可逆性的不育。但用量过大可导致副睾管阻塞和睾丸生精上皮的生精抑制。缩水甘油具有相似性能,虽不引起副睾管阻塞,但对副睾的作用较弱,作用时间较短。二者均为副睾型抗生育药,二者合并用药的方式未见有报导。故本实验是以3-氯丙二醇1 mg/kg 和缩水甘油25mg/kg 合并用药连续口服两天的最低有效量,使厷性大鼠产生短期不育(简称小剂量合剂组),并于不同日期(7、14、30、70天)测定副睾头、尾
3-MCPD has anti-fertility properties, selectively acts on the epididymis, does not affect the mating ability of rats, and can quickly cause reversible infertility. However, excessive use can cause obstruction of the epididymal duct and spermatogenic inhibition of the spermatogenic epithelium. Glycidol has similar properties. Although it does not cause obstruction of the epididymal duct, it has weaker effects on the epididymis and has a shorter duration of action. Both of them are anti-fertility drugs of the epididymal type, and there has been no report on the combination of the two. Therefore, this experiment is based on the combination of 3-chloropropanediol 1 mg/kg and glycidol 25 mg/kg, the minimum effective dose for two consecutive days of oral administration, resulting in short-term infertility in spastic rats (referred to as small dose mixture group), and different Date (7,14,30,70 days) Determination of epididymal head and tail