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目的:评价他克莫司与雷公藤多甙联合治疗口腔扁平苔藓(OLP)的疗效。方法:将纳入研究的89例单纯型OLP患者随机分为3组,分别采用“局部涂抹0.1%他克莫司软膏+口服雷公藤多甙片”、单纯涂抹0.1%他克莫司软膏、单纯口服雷公藤多甙片的方法治疗4周,在治疗结束时和治疗结束半年后分别进行复查,比较各组疗效。结果:联合应用0.1%他克莫司软膏与雷公藤多甙片治疗OLP显示出满意的短期与长期疗效,统计学差异显著,且不良反应轻微。结论:他克莫司与雷公藤多甙联合治疗口腔扁平苔癣疗效满意。
Objective: To evaluate the efficacy of tacrolimus and tripterygium glycosides in the treatment of oral lichen planus (OLP). Methods: Eighty-nine OLP patients were randomly divided into three groups. The patients were treated with topical 0.1% tacrolimus orally and tripterygium wilfordii tablet orally, and 0.1% tacrolimus ointment alone , Simple oral tripterygium glycosides tablet treatment for 4 weeks, at the end of treatment and six months after the end of treatment were reviewed, the efficacy of each group. Results: The combination of 0.1% tacrolimus ointment and tripterygium glycosides tablets showed satisfactory short-term and long-term curative effect in the treatment of OLP with significant statistical difference and slight adverse reactions. Conclusion: Tacrolimus and tripterygium glycosides combined treatment of oral lichen planus with satisfactory results.