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目的观察三氧化二砷联合顺铂腔内注射治疗恶性胸腔积液的疗效和毒副反应。方法 2011年9月-2012年9月,将恶性胸腔积液患者60例,随机分为治疗组和对照组,每组各30例。在胸腔积液充分引流后,治疗组胸腔内注射三氧化二砷20 mg联合顺铂60 mg;对照组只给予胸腔灌注顺铂60 mg,胸腔灌注化学疗法药物两组均1次/周,共3次。观察疗效及不良反应。结果治疗组和对照组的有效率分别为93.3%和56.7%(P<0.05)。治疗组和对照组的一般状况改善率分别为70.0%和40.0%(P<0.05)。两组的不良反应相近。结论三氧化二砷联合顺铂腔内注射治疗恶性胸腔积液具有协同增效作用,不良反应小。
Objective To observe the curative effect and toxicity of intraarticular arsenic trioxide combined with cisplatin in the treatment of malignant pleural effusion. Methods From September 2011 to September 2012, 60 patients with malignant pleural effusion were randomly divided into treatment group and control group, with 30 cases in each group. After the pleural effusion was fully drained, the treatment group received intrathoracic injection of 20 mg of arsenic trioxide together with 60 mg of cisplatin. In the control group, only 60 mg of cisplatin was given to the thoracic cavity. Thoracic perfusion chemotherapy was given once a week for 3 times. Observation of efficacy and adverse reactions. Results The effective rates of the treatment group and the control group were 93.3% and 56.7%, respectively (P <0.05). The general improvement rates of the treatment group and the control group were 70.0% and 40.0%, respectively (P <0.05). Adverse reactions in both groups were similar. Conclusion Intra-arsenic trioxide combined with cisplatin in the treatment of malignant pleural effusion synergies, adverse reactions.