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在世界范围内,肥胖及其相关代谢性疾病的发生率逐年增加,尤其是儿童肥胖症的普遍存在引起了广泛关注。过度肥胖是2型糖尿病、心血管疾病和一些肿瘤的重要危险因素。有关肥胖症的研究过去主要集中在脂肪组织功能改变,脂肪细胞分化,棕色脂肪转化,线粒体功能失调,以及肠道营养物质吸收这些方面的分子生物学研究。肥胖作为一种复杂的代谢紊乱性疾病,基因层面的探索并不能全面体现肥胖的机体内各种参与能量代谢的蛋白质功能的变化。高通量蛋白质组学的应用为研究肥胖的机体蛋白质表达和功能变化提供了可能,并为进一步理解肥胖症的发病机理,寻找疾病相关干预靶点提供了重要的帮助。本综述,总结了近年来关于蛋白质组学在肥胖症病理生理变化中的相关研究,并讨论参与肥胖症发生的可能机制和干预作用靶点。
In the world, the incidence of obesity and its related metabolic diseases is increasing year by year, especially the prevalence of childhood obesity has drawn wide attention. Obesity is an important risk factor for type 2 diabetes, cardiovascular disease and some tumors. Research on obesity has historically focused on the molecular biology of changes in adipose tissue function, adipocyte differentiation, brown fat conversion, mitochondrial dysfunction, and intestinal nourishment absorption. Obesity as a complex metabolic disorders, the exploration of the gene level and can not fully reflect the various obesity body involved in energy metabolism protein function changes. The use of high-throughput proteomics has provided the possibility of studying the protein expression and function changes of obese individuals and has provided important help for understanding the pathogenesis of obesity and finding disease-related intervention targets. This review summarizes recent studies on proteomics in the pathophysiology of obesity and discusses the possible mechanisms involved in the development of obesity and the role of intervention.