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目的 比较丹参、川芎嗪、硫酸镁对妊娠高血压综合征 (简称妊高征 )患者治疗后血中超氧化物歧化酶 (superoxidedismutase,SOD)、脂质过氧化物 (malondialdehyde ,MDA )、血栓素A2(thromboxane2 ,TXA2 )、前列环素I2 (prostaglandlinI2 ,PGI2 )、一氧化氮 (nitricoxide ,NO)、内皮素(endothelinl,ET)及母儿结局的影响。 方法 用丹参、川芎嗪、硫酸镁分别治疗中度妊高征患者各75例 ,观察三组患者治疗前与治疗后SOD、MDA、TXA2 、PGI2 、NO、ET、平均动脉压、产后出血、胎心率异常、新生儿窒息的变化情况。 结果 治疗前后三组SOD(178.3± 4 .1与 2 19.5± 4 .1、190 .4±2 .4与 2 0 8.4± 2 .4、176 .1± 3.4与 2 2 1.1± 2 .2 )mg L、MDA(11.4± 1.3与 7.2± 1.2、13 0± 2 .7与8.6± 2 0、10 .3± 1.5与 7.1± 1.1)mmol L、NO(74 7± 2 0 2与 94 0± 2 32、798± 15 9与 90 7± 14 2、776± 2 12与 86 2± 189)nmol L、ET(78.3± 4 .5与 6 2 .3± 3.8、78.3± 4 .3与 5 8.3± 4 .4、76 .9± 3.9与6 0 .2± 2 .9)ng L、TXA2 (5 6 0± 2 8与 4 86± 2 7、5 37± 2 7与 5 0 2± 2 0、5 5 8± 2 5与 4 72± 2 1) pg L、PGI2(16 2± 13与 2 17± 14、16 7± 17与 2 2 7± 16、16 9± 13与 2 13± 11)pg L
Objective To compare the effects of salvia miltiorrhiza, tetramethylpyrazine and magnesium sulfate on the blood levels of superoxide dismutase (SOD), malondialdehyde (MDA), thromboxane A2 in patients with pregnancy induced hypertension (PIH) (thromboxane2, TXA2), prostaglandin I2 (PGI2), nitric oxide (NO), endothelin1 (ET) and maternal and infant outcomes. Methods Salviae miltiorrhizae, ligustrazine and magnesium sulphate were used to treat 75 cases of moderate PIH respectively. The levels of SOD, MDA, TXA2, PGI2, NO, ET, mean arterial pressure, postpartum hemorrhage, Abnormal heart rate, neonatal asphyxia changes. Results Before and after treatment, the three groups of SOD (178.3 ± 4 .1 and 2 19.5 ± 4 .1, 1904 ± 2 .4 and 20 ± 8.4, 176 ± 1 and 3.4 ± 21.1 ± 2.2) mg L, MDA (11.4 ± 1.3 and 7.2 ± 1.2, 13 ± 2 .7 and 8.6 ± 20, 10.3 ± 1.5 and 7.1 ± 1.1) mmol L, NO (74 7 ± 20 2 and 94 0 ± 2 32,798 ± 15 9 and 90 7 ± 14 2,776 ± 2 12 and 86 2 ± 189) nmol L, ET (78.3 ± 4 .5 vs 62.3 ± 3.8,78.3 ± 4.3 and 5 8.3 ± 4 .4, 76 .9 ± 3.9 and 60.2 ± 2 .9) ng L, TXA2 (56 ± 2 8 and 4 86 ± 2 7,5 37 ± 2 7 and 5 0 2 ± 2 0 , 5 5 8 ± 2 5 and 4 72 ± 2 1) pg L, PGI 2 (16 2 ± 13 and 2 17 ± 14, 16 7 ± 17 and 2 2 7 ± 16, 16 9 ± 13 and 2 13 ± 11) pg L