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目的比较芒硝与50%硫酸镁制剂的临床药学特点。方法结合医院实际,总结芒硝与50%硫酸镁制剂的临床使用情况,查阅文献,采用成本-效果分析法,围绕临床安全性、有效性进行药学比较。结果芒硝使用风险性相对较小,50%硫酸镁制剂使用存在不良反应,有一定的风险性。芒硝在治疗局部水肿、静脉炎、静脉输液渗出、导泻等方面,临床疗效优于50%硫酸镁制剂。芒硝药物经济学评价优于50%硫酸镁制剂。结论芒硝在临床使用的安全性、有效性、经济性方面优于50%硫酸镁制剂。
Objective To compare the clinical pharmacological characteristics of Glauber’s salt and 50% magnesium sulfate preparations. Methods Combined with the actual hospital, the clinical application of Glauber’s salt and 50% magnesium sulfate preparations was summarized. The literature was reviewed, and the cost-effectiveness analysis method was used to compare the safety and efficacy of the two drugs. Results Glauber ’s use of the risk is relatively small, 50% magnesium sulfate preparations used adverse reactions, have a certain risk. Glauber’s salt in the treatment of local edema, phlebitis, intravenous infusion of exudative, cathartic and so on, the clinical efficacy is better than 50% magnesium sulfate preparations. Glauber’s drug economic evaluation is superior to that of 50% magnesium sulfate. Conclusion Glauber’s salt is superior to 50% magnesium sulfate in safety, efficacy and economy of clinical use.