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目的探讨胶质母细胞瘤中基质金属蛋白酶7(MMP-7)的表达及其与患者术后生存期之间相关性。方法采用免疫组织化学法检测60例胶质母细胞瘤组织标本中MMP-7的表达,统计分析其表达强弱与患者术后生存期之间的关系。结果 MMP-7在胶质母细胞瘤中总表达率为73.3%,强表达组生存期明显短于弱表达组(χ2=7.043,P=0.008)。结论 MMP-7可以作为胶质母细胞瘤预后的重要因素之一。
Objective To investigate the expression of matrix metalloproteinase 7 (MMP-7) in glioblastoma and its relationship with the postoperative survival of patients. Methods Immunohistochemical method was used to detect the expression of MMP-7 in 60 cases of glioblastoma tissue samples. The relationship between the expression of MMP-7 and the postoperative survival time was statistically analyzed. Results The overall expression rate of MMP-7 in glioblastoma was 73.3%. The survival of the strong expression group was significantly shorter than that of the weak expression group (χ2 = 7.043, P = 0.008). Conclusion MMP-7 may be one of the important prognostic factors of glioblastoma.