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30例肾脏病患者资料分析,提示肾脏病时糖耐量降低,尿毒症时更为显著,表现为糖尿病样曲线。肾脏病时空腹胰岛素,C肽水平显著高于正常人,尿毒症时尤为突出。口服葡葡糖后尿毒症的血胰岛素、C肽水平显著高于肾病综合征和氨质血症,由此可以说明肾脏病时胰岛β细胞分泌增加。肾脏病时血胰高糖素水平增高。高胰高糖素血症是由于胰高糖素在肾脏降解减少之故,同时起了胰岛素抗力的作用,参与糖代谢紊乱的机理。在临床上,BUN、Cr和胰岛素、C肽密切相关。
Data analysis of 30 cases of patients with kidney disease, suggesting that kidney disease, decreased glucose tolerance, uremia is more significant when the performance of diabetes-like curve. Nephrotic fasting insulin, C-peptide levels were significantly higher than normal, uremia is particularly prominent. After oral administration of glucose, uremia blood insulin, C-peptide levels were significantly higher than those of nephrotic syndrome and hyperamustine, which can explain the increase of pancreatic β-cell secretion in kidney disease. Kidney disease increased blood glucagon levels. High glucagon hyperlipidemia is due to the reduction of glucagon in the kidneys, so insulin resistance plays a role in the mechanism of glucose metabolism disorders. Clinically, BUN, Cr and insulin, C-peptide is closely related.