论文部分内容阅读
目的 :探讨银杏叶制剂对心绞痛患者的抗氧化和抗脂质过氧化作用。方法 :检测了 78例心绞痛患者经银杏叶制剂“天宝宁”治疗前后的血浆维生素C(P -VC)、维生素E(P -VE)、β -胡萝卜素 (P -β -CAR)、过氧化脂质 (P-LPO)以及红细胞超氧化物歧化酶 (E -SOD)、过氧化氢酶 (E -CAT)、谷胱甘肽过氧化物酶 (E -GSH -PX)、过氧化脂质 (E -LPO)值。结果 :与治疗前比较 ,治疗后的P -VC、P -VE、P -β -CAR、E -SOD、E -CAT、E -GSH -PX平均值均显著升高 (P <0 .0 0 1 ) ,P -LPO、E -LPO平均值均显著降低 (P <0 .0 0 1 ) ,与对照组比较无显著差异 (P >0 .0 5)。结论 :心绞痛患者体内的病理性氧化反应和脂质过氧化反应在治疗后明显减缓 ,银杏叶制剂具有较强的抗氧化损伤和抗脂质过氧化损伤作用
Objective: To investigate the anti-oxidation and anti-lipid peroxidation effects of Ginkgo biloba extract on patients with angina pectoris. METHODS: Plasma vitamin C (P-VC), vitamin E (P-VE), β-carotene (P-β-CAR), and peroxidation were measured in 78 patients with angina pectoris before and after Ginkgo biloba extract “Tianbaoning”. Lipids (P-LPO) and Erythrocyte Superoxide Dismutase (E-SOD), Catalase (E-CAT), Glutathione Peroxidase (E-GSH-PX), Lipid Peroxide (E-LPO) value. Results: Compared with before treatment, the mean values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT, and E-GSH-PX were significantly increased after treatment (P < 0.05). 1) The mean values of P-LPO and E-LPO were significantly decreased (P < 0.01), and there was no significant difference from the control group (P > 0.05). Conclusion: The pathological oxidation and lipid peroxidation in patients with angina pectoris were significantly slowed down after treatment. Ginkgo biloba extract has strong anti-oxidative and anti-lipid peroxidative effects.