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本文应用流行病学中病例对照研究方法对144对原发性肝癌病例及其对照作了研究。结果表明,病例组一级亲属中原发性肝癌累积发病率高于对照组(x~2=8.37,P<0.005,RR=17.67)。遗传度为56.8±5.44%。将病例与对照有无肝癌史作为一个因素,对58例有HBV检测数据的肝癌病例及其按1:2配比的116例对照进行分析,其家族肝癌史为有意义变量(Z=2.15,P=0.03,OR=10.85),在向HBsAg等其它影响原发性肝癌发病的因素调整后,肝癌家族史仍有意义(Z=2.05,P=0.04,OR=10.85)。结果表明,遗传因素可能在原发性肝癌发病中起了较重要的作用。
In this paper, 144 cases of primary liver cancer and its controls were studied using a case-control study in epidemiology. The results showed that the cumulative incidence of primary liver cancer in the first-degree relatives of the case group was higher than that in the control group (x~2=8.37, P<0.005, RR=17.67). Heritability is 56.8±5.44%. The history of cases and controls with or without hepatocellular carcinoma as a factor was analyzed in 58 cases of liver cancer patients with HBV detection data and 116 controls according to a ratio of 1:2. The family history of hepatocellular carcinoma was a meaningful variable (Z=2.15, P = 0.03, OR = 10.85). After adjustment for other factors that affect the onset of primary liver cancer such as HBsAg, the family history of HCC remains significant (Z = 2.05, P = 0.04, OR = 10.85). The results show that genetic factors may play an important role in the pathogenesis of primary liver cancer.