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目的 :为研究日本血吸虫病流行区人群中特异性抗体水平是否为再感染的危险因素。方法 :选择江西省新建县鄱阳湖一小岛上三个毗邻的自然村作为观察试区 ,调查 196名 ( 3- 2 5岁 )感染者中 ,吡喹酮治疗后粪检阴性的 138人经过一个感染季节后再感染的情况 ,并检测其血清特异性同型限制性抗体水平。同时就人群接触疫水的暴露水平及年龄因素、血样中特异的同型限制性抗体水平诸因素同再感染的关系进行非条件 logistic回归分析。结果 :虫卵可溶性抗原和粗制成虫抗原特异的 Ig G4抗体水平是再感染发生的危险因素 ,危险度分别是 2 .83和 2 .4 0。结论 :本研究结果可能成为构建对再感染易感状态作预测性诊断试验的基础。
Objective: To investigate whether the level of specific antibodies in the population of schistosomiasis japonica is a risk factor for reinfection. Methods: Three adjacent natural villages on an island of Poyang Lake, Xinjian County, Jiangxi Province were selected as the observation area. Of 196 patients (3-25 years old) who were tested for infection, 138 Infection after the seasons of infection, and detect the level of serum-specific isotype-restricted antibodies. At the same time, non-conditional logistic regression analysis was conducted on the relationship between the exposure level and age factor of exposure to contaminated water, the level of the specific isotype-restricted antibody in blood samples and re-infection. RESULTS: The levels of Ig G4 antibody specific for antigen and crude adult worm antigen were risk factors for reinfection, with a risk of 2.83 and 2.04, respectively. CONCLUSIONS: The results of this study may underlie the construction of a predictive diagnostic test for susceptibility to reinfection.