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目的 探讨银屑病病人的血清白细胞介素(IL)-36及其受体拮抗剂IL-36Ra的表达水平与银屑病病情的严重程度的相关性.方法 选取我院2013年6月至2014年5月寻常型银屑(PV)病人50例,脓疱型泛发型银屑病(GPP)病人50例,同时选择体检健康者50例为对照,利用酶联免疫吸附试验法(ELISA)检测研究对象的血清IL-36γ 、IL-36β、IL-36α和IL-36Ra水平,比较PV组与对照组、GPP组与对照组的IL-36和IL-36Ra水平;同时比较病情不同严重程度病人的IL-36γ、IL-36β、IL-36α和受体拮抗剂IL-36Ra水平.结果 PV组的血清中IL-36γ、IL-36β、IL-36α水平高于对照组,IL-36Ra水平低于对照组,差异有统计学意义(P ＜0.05);GPP组的IL-36γ、IL-36β、IL-36α高于对照组,IL-36Ra低于对照组,差异有统计学意义(P＜0.05);GPP脓疱发作组的血清IL-36γ、 IL-36β、IL-36α和IL-36Ra水平高于GPP脓疱消退组,差异有统计学意义(P＜0.05),IL-36γ 、IL-36β、IL-36α和受体拮抗剂IL-36Ra水平PV进展期高于非进展期(P＜0.05),同时GPP中度、重度患者IL-36表达水平与对照组比较差异明显(P＜0.05).结论 银屑病的病情严重程度与IL-36水平和IL-36Ra水平密切相关.“,”Methods The level of serum IL-36γ, IL-36β, IL-36αand receptor antagonist IL-36Ra was tested by enzyme linked immunosorbent assay (ELISA) in 50 patients with psoriasis vulgaris(PV), 50 patients with generalized pustular psoriasis(GPP) and 50 healthy people.Recruitment occurred between June 2013 to May 2014.The healthy people were admitted into the hospital for physical examination.The levels of serum IL-36 and receptor antagonist IL-36Ra was compared between PV group, GPP group and the control group, and the levels of serum IL-36γ, IL-36β, IL-36αand receptor antagonist IL-36Ra was also compared in patients with different disease severity.Results The level of serum IL-36γ, IL-36β, IL-36αin PV group was significantly higher than those in the control group while the level of receptor antagonist IL-36Ra was lower, and the differences was statistically significant (P ＜ 0.05);The level of the serum IL-36γ, IL-36β, IL-36αin GPP group was significantly higher than thosein the control group while the level of receptor antagonist IL-36Ra was lower, and the differences was statistically significant (P ＜ 0.05).Meanwhile, the levelof IL-36 has significant differences between moderate and severe GPP group and the control group (P ＜ 0.05).The comparison of the of IL-36 level between patients with mild PV and patients with severe GPP, and comparison between patients with moderate or severe GPP and mild GPP were statistically significant (P ＜ 0.05).Conclusion The level of serum IL-36 and receptor antagonist IL-36Ra are closely related with the severity of psoriasis