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单纯以热或各种方式的热与电离幅射结合治疗癌肿已有多年历史。1866年,一位德国医生报告1例2次患丹毒而发高热的病人,他面部的肉瘤消失2年。27年后Coley描述38例晚期癌肿病人,他们亦因丹毒的细菌毒素而发高热。其中12人完全治愈,2例分别带瘤存活7和27年。复习1918年文献,Rohdenbury注意到166个癌肿自动消退的患者,其中72例不是曾发高热就是曾在局部施用过热疗。1913年,Muller报告100例用放射和热两种方法治疗的晚期癌肿病人:36例肿瘤仅暂时消退;32例完全治愈。1940年后有多篇文章描述热和/或放射对细胞培养,实验动物和晚期癌肿病人的作用。然而,在确切的治疗时间、剂量、热和放射的应用次序方面还没有统一的意见。作者于1974年开始研究热和放射结合对晚期或有症状的复发性癌肿病人进行姑息治疗。
The treatment of cancer with heat or various forms of heat and ionizing radiation alone has been for many years. In 1866, a German doctor reported 1 case of erysipelas and fever, and his facial sarcoma disappeared for 2 years. After 27 years Coley described 38 patients with advanced cancer, and they also developed high fever due to bacterial toxins of erysipelas. Of these, 12 were completely cured, and 2 patients survived for 7 and 27 years, respectively. Reviewing the 1918 literature, Rohdenbury noted 166 patients with automating cancer regressions, of which 72 had either had hyperthermia or had locally applied hyperthermia. In 1913, Muller reported 100 cases of advanced cancer patients treated with both radiation and heat: 36 cases had only temporary regression; 32 cases were completely cured. After 1940 there were several articles describing the effects of heat and/or radiation on cell culture, experimental animals, and advanced cancer patients. However, there is no consensus on the exact timing of treatment, dosage, heat, and application of radiation. In 1974, the authors studied the combination of heat and radiation for palliative care in patients with advanced or symptomatic recurrent cancers.