在纸浆生产或纸张加工过程中,可产生四氯二苯并对二(口恶)(口英)(TCDD)和其他的多氯二苯并对二(口恶)(口英)。TCDD在土壤里的半减期长达10～12年;进入人体内的TCDD,其半减期为7年。因此,TCDD的皮肤接触和经皮吸收问题已引起人们的关注。本文旨在研究接触低剂量TCDD的经皮吸收、分布和排出规律。实验用~3H-TCDD标记物,比放射性36Ci/mmol,放化纯度>98％。选Fischer 344雄性大鼠,体重220±9 g。在涂皮前24 h,将大鼠背部肩胛间区剃毛,然后涂布~3H-TCDD200 pmol或111 pmol/cm~2(溶于60μl丙酮),相当于1 nmol/kg剂量。涂皮后,在涂药部位复盖打孔的不锈钢“帽”,每只大鼠单独饲养于代谢笼内,收集其粪尿。在给药后第1,4,8,12,24,48,72和120小时,分别处死动物,取肝、皮肤、脂肪组织、肌肉、肾、肾上 Tetrachlorodibenzo-p-dioxins (TCDD) and other polychlorinated dibenzo-p-dioxins (TCDD) can be produced during pulp production or paper processing. TCDD half-life in the soil up to 10 to 12 years; into the body of TCDD, the half-period of 7 years. Therefore, the problem of skin contact and percutaneous absorption of TCDD has drawn people’s attention. The aim of this study was to study the percutaneous absorption, distribution and discharge of low-dose TCDD. ~ 3H-TCDD markers were used for experiments, specific radioactivity was 36 Ci / mmol and radiochemical purity was> 98%. Fischer 344 male rats weighing 220 ± 9 g were selected. Twenty-four hours before application, sharks were dissected from the back of the rat’s scapular region and then coated with ~ 3H-TCDD200 pmol or 111 pmol / cm ~ 2 (dissolved in 60 μl of acetone) corresponding to a dose of 1 nmol / kg. After coating, perforated stainless steel “caps” were applied to the applicator site. Each rat was housed separately in a metabolic cage to collect its excrement. At 1, 4, 8, 12, 24, 48, 72 and 120 hours after the administration, animals were sacrificed and liver, skin, adipose tissue, muscle, kidney and kidney