论文部分内容阅读
用放免法测定３８例糖尿病人及１０例正常人血浆内皮素浓度。结果显示无并发症的病人血浆内皮素与正常对照无显著差异；有视网膜、肾等并发症而无高血压的病人血浆内皮素较正常人显著增高（Ｐ＜０．０１）；而有上述并发症又有高血压的病人血浆内皮素明显升高，与无高血压的并发症组相比差异有显著性（Ｐ＜０．０１）。内皮素可能在糖尿病并发症的发展中起着一定的病理生理作用。内皮素增高可以作为判断糖尿病出现血管并发症的一个指标。
The radioimmunoassay was used to determine plasma endothelin levels in 38 patients with diabetes mellitus and 10 normal controls. The results showed that there was no significant difference between the plasma endothelin and normal controls in patients without complications; the plasma endothelin levels in patients with complications of retinal and renal hypertension without hypertension were significantly higher than those in normal controls (P <0.01) Patients with hypertension and hypertension plasma endothelin was significantly higher, compared with no complications of hypertension group was significantly different (P <0.01). Endothelin may play a pathophysiological role in the development of diabetic complications. Increased endothelin can be used as an indicator of vascular complications of diabetes.