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目的对东北红豆杉(Taxus cuspidataSieb.et Zucc.)的化学成分进行研究。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和NMR波谱数据进行结构鉴定。结果分离得到8个化合物,分别鉴定为柳杉酚(sugiol,1)、20-羟基蜕皮酮(20-hydroxyecdysone,2)、davidioside B(3)、表儿茶素(epicatechin,4)、2-去乙酰氧基-7β,9α-二去乙酰基紫杉宁J(2-deacetoxy-7β,9α-dideacetyl-taxinine J,5)、2-去乙酰氧紫杉宁E(2-deacetoxytaxinine E,6)、7-表-10-去乙酰基巴卡亭III(7-epi-10-deacetyl baccatin III,7)、7-O-β-D-木糖-10-乙酰基巴卡亭III(7-O-β-D-xylose-10-deacetyl baccatin III,8)。结论化合物3为首次从红豆杉属植物中得到,化合物1、5、7、8为首次从东北红豆杉植物中分离得到,并利用二维核磁共振技术首次对化合物6的碳谱数据进行了全归属。
Objective To study the chemical constituents of Taxus cuspidata Sieb.et Zucc. Methods The compounds were isolated by silica gel column chromatography and identified by physicochemical properties and NMR spectroscopy. Results Eight compounds were isolated and identified as sugiol (1), 20-hydroxyecdysone (2), davidioside B (3), epicatechin Deacetoxy-7β, 9α-dideacetyl-taxinine J (5), 2-deacetoxytaxinine E (6) ), 7-ep-10-deacetyl baccatin III (7), 7-O-β-D-xylose- -O-β-D-xylose-10-deacetyl baccatin III, 8). Conclusion Compound 3 was obtained from Taxus for the first time. Compounds 1, 5, 7 and 8 were isolated from Taxus cuspidata for the first time. The data of compound 6 were first analyzed by two-dimensional nuclear magnetic resonance Belonging.