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目的观察朝藿定C与淫羊藿苷对去卵巢小鼠子宫的作用。方法取昆明种雌性小鼠,手术摘除双侧卵巢,术后3天随机分为8组:模型组、己烯雌酚组、朝藿定C高、中、低剂量组及淫羊藿苷高、中、低剂量组,另设假手术组。连续给药60 d后,处死动物,观测动物子宫系数(UC)、子宫内膜厚度(ET)和子宫腺体直径(UGD)。结果与假手术组比较,模型组UC、ET和UGD明显降低。与模型组比较,淫羊藿苷高、中、低组的UC、UGD明显增加;朝藿定C高、中、低组的UC、UGD明显增加,而ET增加不明显。结论淫羊藿苷和朝藿定C均具有拟雌激素样作用,但淫羊藿苷拟雌激素样作用高于朝藿定C。
Objective To observe the effect of Epimedin C and icariin on the uterus of ovariectomized mice. Methods Female Kunming mice were randomly divided into 8 groups: model group, diethylstilbestrol group, epimedin C high, medium and low dose groups and icariin high, Low-dose group, another set of sham-operated group. After continuous administration for 60 days, the animals were sacrificed and the animal’s uterine coefficient (UC), endometrial thickness (ET) and uterine gland diameter (UGD) were observed. Results Compared with sham operation group, UC, ET and UGD in model group decreased significantly. Compared with model group, the UC, UGD of high, medium and low groups of icariin increased obviously; UC and UGD of high, middle and low group of epimedin C increased obviously, while ET increased insignificantly. Conclusion Both icariin and epimedin C have estrogenic effects, but the estrogen-like effect of icariin is higher than that of epimedin C.