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目的 :研究复方冬虫夏草多糖脂质体口服液对慢性乙型肝炎的疗效。方法 :应用脂质体包裹虫草多糖、黄芪、丹参制成口服液 ,治疗慢性乙型肝炎 5 2例并与 4 0例一般保肝药物治疗患者进行对照。结果 :治疗 3个月后 ,治疗组与对照组ALT复常率分别是 6 5 .4 %和 4 2 .5 % (P <0 .0 5 ) ,HBeAg阴转率分别为 34.6 %和 2 .5 % (P <0 .0 1) ,HBV DNA阴转率分别为4 2 .3%和 5 % (P <0 .0 1) ,治疗前后血清透明质酸、Ⅳ型胶原、层粘蛋白治疗组均明显下降 (P <0 .0 1)对照组无显著变化 (P >0 .0 5 )。结论 :复方虫草多糖脂质体口服液治疗慢性乙型肝炎对改善肝功能、抗病毒及抗纤维化具有良好的效果。
Objective: To study the curative effect of compound Cordyceps liposome oral liquid on chronic hepatitis B Methods: Liposomes were used to coat Cordyceps polysaccharide, Astragalus and Salvia miltiorrhiza into oral solution, 52 cases of chronic hepatitis B were treated and compared with 40 cases of general liver protection drugs. Results: After 3 months of treatment, the rates of ALT recurrence in the treatment group and the control group were 65.4% and 42.5%, respectively (P <0.05), and the negative rates of HBeAg were 34.6% and 2 respectively. 5% (P <0.01), HBV DNA negative conversion rates were 42.3% and 5% (P <0.01), before and after treatment of serum hyaluronic acid, type Ⅳ collagen, laminin therapy (P <0.01) in the control group showed no significant change (P> 0.05). Conclusion: The compound Cordyceps liposomes oral liquid treatment of chronic hepatitis B to improve liver function, anti-virus and anti-fibrosis with good results.