论文部分内容阅读
目的 :研究各类抗抑郁剂对小鼠探究行为 ,自主活动性以及隔离攻击行为的药理作用 ,进一步探讨它们抗攻击行为不同的药理学机制。方法 :采用隔离小鼠攻击行为的模型 ,评价各类抗抑郁剂对隔离攻击行为的作用。测定各类抗抑郁剂对群居小鼠探究行为和自主活动性的影响。结果 :(1)米安色林 (0 .5～ 5mg·kg-1) ,丁螺环酮(2 .5～ 10mg·kg-1)和吗氯贝胺 (2 .5～ 10mg·kg-1) ,显著性抑制群居小鼠的探究行为 ,但是 ,氟西汀 (2 .5～ 10mg·kg-1)、丙米嗪 (2 .5～ 10mg·kg-1)和DOI (0 .5～ 2mg·kg-1)对其无明显影响 ;(2 )米安色林和丁螺环酮明显减少群居小鼠的自主活动性 ,而氟西汀、丙米嗪、吗氯贝胺以及DOI无此作用 ;(3)氟西汀 ,米安色林 ,丙米嗪和丁螺环酮剂量依赖性拮抗隔离小鼠的攻击行为 ,吗氯贝胺对此无明显影响。DOI双向调节隔离小鼠的攻击行为。结论 :本实验结果提示 ,氟西汀、米安色林、丁螺环酮、丙米嗪以及DOI对小鼠的探究行为、自主活动性和隔离攻击行为的药理作用并不完全相同 ,可能与它们不同的药理学机制有关。5 HT1A和 5 HT2A/ 2C受体可能介导隔离小鼠的攻击行为 ,有关 5 HT受体亚型介导攻击行为需作进一步研究。
OBJECTIVE: To study the pharmacological effects of various antidepressants on exploring behavior, autonomous activity and isolation attack in mice, and to further explore their pharmacological mechanisms with different anti-attack behaviors. METHODS: A model of isolated offensive behavior in mice was used to evaluate the effect of various antidepressants on isolated offensive behavior. The effects of various antidepressants on the inquiry behavior and voluntary activity of the mice in the community were determined. Results: (1) Mianserin (0.5 ~ 5 mg · kg -1), buspirone (2.5 ~ 10 mg · kg -1) and moclobemide (2.5 ~ 10 mg · kg -1) 1), and significantly inhibited the exploring behavior of the mice in the community. However, fluoxetine (2.5 ~ 10 mg · kg -1), immeprazole (2.5 ~ 10 mg · kg -1) and DOI ~ 2mg · kg-1) had no significant effect on them; (2) Mianserin and buspirone significantly reduced spontaneous activity in swine mice, whereas fluoxetine, imipramine, moclobemide and DOI (3) Fluoxetine, mianserin, imipramine and buspirone dose-dependently antagonized the challenge of isolated mice, moclobemide had no significant effect on this. DOI bidirectionally modulates the aggressive behavior of isolated mice. CONCLUSION: The results of this experiment suggest that the pharmacological effects of fluoxetine, mianserin, buspirone, imipramine, and DOI on exploratory behavior, voluntary activity and isolation attack in mice are not all the same and may be related to Their different pharmacological mechanisms. 5 HT1A and 5 HT2A / 2C receptors may mediate the challenge behavior in isolated mice, and further investigation of 5 HT receptor subtype-mediated aggressive behavior is warranted.