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干扰素及同种异基因骨髓移植代表了慢性粒细胞白血病治疗近10余年来的主要进展。异基因骨髓移植被公认是一种可治愈慢性粒细胞白血病的有效方法。干扰素可使20%慢性性细胞白血病病人产生完全细胞遗传学缓解,少数病人 ABL/BCR 基因重组消失。本文综述两种疗法的具体方法、疗效及目前治疗中存在的问题。
Interferon and allogeneic bone marrow transplantation represent the major advances in the treatment of chronic myelogenous leukemia for more than a decade. Allogeneic bone marrow transplantation is recognized as an effective method to cure chronic myelogenous leukemia. Interferon can produce complete cytogenetic remission in 20% of patients with chronic cell leukemia, and the reorganization of ABL/BCR genes disappears in a minority of patients. This article reviews the specific methods, efficacy, and current problems in both therapies.