本文报道了与α-人心房肽(α-hANP)的A_1—A_4四肽及A_5—A_(10),A_(11)—A_(16),A_(17)—A_(22),A_(23)—A_(28)四个六肽片段对应的带保护基片段的液相法合成。在有些肽段的合成中,比较了混合酸酐法和活泼酯法所得的结果。在另一些肽段的合成中,观察了反应温度、催化剂的碱性及反应时间对产物产率的影响。上述带保护基的片段均由快原子轰击质谱测定氨基酸顺序,确认结构准确无误。 In this paper, we report the relationship between A_4_A_4 tetrapeptide and A_5_A_ (10), A_ (11) -A_ (16), A_ (17) -A_22, A_ 23) -A_ (28) Four hexapeptide fragments corresponding to the protected fragment with liquid phase synthesis. In the synthesis of some peptides, the results of mixed anhydride method and active ester method were compared. In the synthesis of other peptide fragments, the effects of reaction temperature, basicity of catalyst and reaction time on product yield were observed. The above protected fragment was determined by fast atom bombardment mass spectrometry amino acid sequence to confirm the structure is correct.