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目的:探讨贲门癌癌旁与无症状人群贲门黏膜活检肠上皮化生(IM)组织中p53和PCNA的表达状况。方法:采用免疫组织化学ABC法研究了70例贲门癌癌旁IM与320例无症状人群贲门黏膜活检IM组织中p53和PCNA蛋白的表达。结果:无症状人群贲门黏膜活检标本中IM检出率4.4%(14/320),低于贲门癌癌旁组织中的38.6%(24/70)(P<0.01)。癌旁IM组织中p53蛋白高表达率高于无症状人群IM(χ2=8.7840,P<0.01),但PC-NA蛋白阳性表达率差异无统计学意义(χ2=1.0788,P>0.05)。结论:贲门癌癌旁IM可能更易发生基因改变。
OBJECTIVE: To investigate the expression of p53 and PCNA in gastric mucosa biopsy intestinal metaplasia (IM) tissues of patients with gastric cardia cancer and asymptomatic patients. Methods: Immunohistochemical ABC method was used to study the expression of p53 and PCNA proteins in 70 cases of gastric cardia mucosa biopsy IM and 320 cases of asymptomatic gastric cardia adjacent to IM. Results: The detection rate of IM in cardia mucosa biopsy specimens in asymptomatic subjects was 4.4% (14/320), which was lower than that in gastric cancer adjacent tissues (38.6%, 24/70) (P <0.01). The high expression rate of p53 protein in adjacent non-cancerous tissues was higher than that in asymptomatic group (χ2 = 8.7840, P <0.01). However, there was no significant difference in the positive expression rate of PC-NA protein between two groups (χ2 = 1.0788, P> 0.05). Conclusion: Cardiac cancer adjacent to IM may be more prone to genetic changes.