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目的 观察佩尔地平和乌拉地尔在肩关节镜手术中控制性降压的临床效果.方法 40例全身麻醉下肩关节镜择期手术患者随机均分为两组:麻醉诱导后,P组静脉注射佩尔地平10-20μg/kg,继之持续泵注1-5 μg·kg-1·min-1;U组静脉注射乌拉地尔12.5-37.5mg,继之持续泵注3-10μg·kg1·min1.记录围降压期血压和心率变化、术野质量及不良反应.结果 两组手术期间降压效果皆满意.P组在降压5 min时血压低于U组,在停药后10 min时血压高于U组(P<0.05),心率稍快于U组(P>0.05).两组术野质量评分相仿(P>0.05),均未发生明显的不良反应.结论 佩尔地平和乌拉地尔用于肩关节镜手术的控制性降压均安全有效.“,”Objective To investigate the clinical efficacy of perdipine and urapidil used for deliberate hypotension during shoulder arthroseopic surgery.Methods Forty patients undergoing selective shoulder arthroscopic surgery under general anesthesia were equally randomized into two groups.After anesthesia induction,the deliberate hypotension in group P was performed with perdipine 10-20μg/kg bolus injection and followed by 1-5 μg · kg-1 · min-1 infusion,and that in group U with urapidil 12.5-37.5 mg bolus injection and followed by 3-10 μg · kg1 · min-1 infusion.The blood pressure (BP) and heart rate (HR),quality of surgery field and adverse reactions were recorded.Results The BP at 5 min during deliberate hypotension was lower in group P than that in group U,which at 10 min after deliberate hypotension was higher in group P than that in group U (P<0.05).The BP was controlled satisfactorily in two groups.The HR during hypotension was slightly quickerin group P than that in group U(P>0.05).There was no significant difference in the quality of surgery field between two groups(P>0.05).No obvious adverse reactions were observed in two groups.Conclusion Perdipine and urapidil are effective and safe for deliberate hypotension.