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目的:观察温经活血通络汤泡洗合用维生素B12足三里穴位注射预防奥沙利铂周围神经毒性的临床疗效。方法:将采用含奥沙利铂的FOLFOX4方案化疗的胃癌、结直肠癌患者64例应用随机对照的方法分为2组,治疗组32例,化疗期间用温经活血通络汤泡洗手足,并同时予维生素B12足三里穴位注射;对照组32例,化疗期间同时口服甲钴胺片。2组均以14d为1个周期,共治疗4个周期,观察比较2组奥沙利铂所致神经毒性的发生率及毒性分级水平。结果:奥沙利铂所致神经毒性的发生率治疗组为25.00%,对照组为56.25%,2组比较,差异有统计学意义(P<0.05)。结论:温经活血通络汤泡洗合用维生素B12足三里穴位注射对奥沙利铂相关的神经毒性有显著的防治作用。
Objective: To observe the clinical efficacy of Wenjinghuoxuetongluo decoction combined with vitamin B12 injection in preventing peripheral neurotoxicity of oxaliplatin. Methods: Sixty-four patients with gastric cancer and colorectal cancer who were treated with oxaliplatin-containing FOLFOX4 regimen were randomly divided into two groups: treatment group (32 cases), hand-foot-wash with warm blood, At the same time to vitamin B12 injection of Zusanli points; control group of 32 patients, while oral mecobalamin tablets during chemotherapy. The two groups were 14d for a cycle, a total of four cycles of treatment, observed and compared the incidence of oxaliplatin 2 groups of neurotoxicity and toxicity level. Results: The incidence of neurotoxicity induced by oxaliplatin was 25.00% in the treatment group and 56.25% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: Wenjing Huoxue Tongluo decoction combined with vitamin B12 injection of Zusanli points can significantly prevent oxaliplatin-related neurotoxicity.