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目的:探究前列腺癌根治术在不同危险度前列腺癌患者中治疗的临床效果,为临床前列腺癌患者的治疗提供依据。方法:选择2008年1月~2015年12月期间我院94例前列腺癌患者为研究对象,根据D’Amico评分将其分为高危、中危及低危三组,收集患者基线资料、术后随访资料,并比较三组手术并发症;采用Kaplan-Meier分析法计算三组患者生存率,并采用Log-rank检验比较不同危险组的生存率。结果:高危组患者进行开放性手术人数多于中危组和低危组,且中危组多于低危组,差异具有统计学意义(P<0.05);高危组患者术前Gleason评分和PAS水平高于中危组和低危组,且中危组高于低危组,差异具有统计学意义(P<0.05);术后5年高危组患者完全控尿率显著低于中危组和低危组(P<0.05);三组患者间5年无生化复发率比较无统计学意义(P>0.05)。结论:前列腺癌根治术治疗高危前列腺患者较中、低危患者疗效较差,但仍可达到较好的疗效,可在临床推广使用。
Objective: To investigate the clinical effect of radical prostatectomy in patients with different risk of prostate cancer and provide the basis for the treatment of patients with clinical prostate cancer. Methods: A total of 94 prostate cancer patients from January 2008 to December 2015 in our hospital were selected as study subjects. According to D’Amico score, they were divided into three groups: high risk, intermediate risk and low risk. The baseline data were collected and followed up Data were compared with those of the three groups. Survival rates of three groups were calculated by Kaplan-Meier analysis and Log-rank test was used to compare the survival rates of different risk groups. Results: The number of open surgery in high-risk group was more than that in moderate-risk group and low-risk group, more in intermediate-risk group than in low-risk group (P <0.05). The Gleason score and PAS (P <0.05). The rate of complete control of urine in the high-risk group was significantly lower than that in the moderate-risk group at 5 years Low-risk group (P <0.05). There was no significant difference in five-year biochemical recurrence rate among the three groups (P> 0.05). Conclusion: Radical prostatectomy for patients with high-risk prostate cancer is less effective than moderate and low-risk patients, but it can still achieve better therapeutic effect and can be used clinically.