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目的:观察血液灌流联合血液透析对减少尿毒症患者慢性并发症的效果。方法:选择在我院行规律血液透析的尿毒症60例,随机分为对照组和观察组各30例。对照组采用常规血液透析治疗,观察组采用血液透析联合血液灌流治疗。比较两组治疗前后透析前血红蛋白(Hb)、血肌酐(SCr)、尿素氮(BUN)、钙、磷、甲状旁腺激素(PTH)、超敏C反应蛋白(hs-CRP)水平及透析前平均动脉压改善情况。结果:治疗1年后,观察组透析前Hb水平显著高于对照组,血磷、PTH、透析前平均动脉压显著低于对照组(P<0.05);两组校正钙、BUN、SCr、hs-CRP水平比较,差异不显著(P>0.05)。结论:血液灌流联合血液透析,可改善尿毒症患者贫血、高血压病、高磷血症和继发性甲状旁腺功能亢进症等慢性并发症情况。
Objective: To observe the effect of hemoperfusion combined with hemodialysis on reducing chronic complications in patients with uremia. Methods: 60 cases of regular hemodialysis uremia in our hospital were randomly divided into control group and observation group of 30 cases. The control group was treated with routine hemodialysis, and the observation group was treated with hemodialysis combined with hemoperfusion. The levels of hemoglobin (Hb), serum creatinine (SCr), blood urea nitrogen (BUN), calcium, phosphorus, PTH and hs-CRP before and after dialysis were compared between pretreatment and before dialysis Average arterial pressure to improve the situation. Results: After 1 year of treatment, the level of Hb in the observation group before dialysis was significantly higher than that in the control group. The mean arterial pressure before and after dialysis was significantly lower than that of the control group (P <0.05). The levels of calcium, BUN, SCr, hs -CRP levels, the difference was not significant (P> 0.05). Conclusion: Hemoperfusion combined with hemodialysis can improve the chronic complications such as anemia, hypertension, hyperphosphatemia and secondary hyperparathyroidism in patients with uremia.