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目的了解两种重组乙肝疫苗免疫效果,为成人免疫接种提供参考。方法将152名成人随机分为2组,按0、1、6个月免疫程序分别接种重组酵母乙肝疫苗和重组CHO乙肝疫苗,全程免疫后1个月检测血清抗-HBs阳转率和抗-HBs平均几何滴度(GMT),同时观察所有接种对象的不良反应。结果重组酵母乙肝疫苗和重组CHO乙肝疫苗的抗-HBs阳转率为89.04%和91.14%,抗-HBs几何平均滴度分别为202.99mIU/mL和201.98mIU/mL,两者均无明显差别。不同性别、不同年龄人群对两种疫苗的免疫效果也无明显差别,但肥胖者抗-HBs阳转率要明显低于其他人群。所有接种对象未发现明显的异常反应。结论重组酵母和重组CHO乙肝疫苗均有较好的免疫原性和安全性。
Objective To understand the immune effect of two recombinant hepatitis B vaccines and provide reference for adult immunization. Methods 152 adult patients were randomly divided into two groups. The recombinant yeast Hepatitis B vaccine and recombinant CHO hepatitis B vaccine were inoculated respectively according to the immunization schedules of 0, 1, and 6 months. The positive rate of anti-HBs and anti- HBs average geometric titers (GMT), while observing all inoculated adverse reactions. Results The anti-HBs positive rates of recombinant yeast Hepatitis B vaccine and recombinant CHO hepatitis B vaccine were 89.04% and 91.14%, respectively. The geometric mean titers of anti-HBs were 202.99 mIU / mL and 201.98 mIU / mL, respectively, with no significant difference between the two. There was no significant difference in the immune effect between the two vaccines in different genders and different age groups, but the positive rate of anti-HBs in obese people was significantly lower than that in other populations. All vaccinated subjects found no obvious abnormal reaction. Conclusion Recombinant yeast and recombinant CHO hepatitis B vaccine have good immunogenicity and safety.