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目的:观察α-硫辛酸对糖尿病眼球运动神经麻痹的疗效。方法:收治糖尿病眼球运动神经麻痹患者52例(52眼),采用随机法分为对照组26例(26眼)和治疗组26例(26眼),在原有常规治疗并改善微循环治疗基础上,治疗组给予α-硫辛酸肌肉注射,1次/日,14天后进行两组眼位、眼球运动、复视像检查及血清氧化应激指标检测。结果:治疗组与对照组的综合有效率分别为88.46%、61.54%(P<0.05),显效率分别为46.15%,11.54%(P<0.01)。治疗后超氧化物歧化酶(SOD)水平升高,丙二醛(MDA)水平降低。结论:α-硫辛酸对糖尿病眼肌麻痹有明显的治疗作用。
Objective: To observe the effect of α-lipoic acid on diabetic motor nociceurism. Methods: Fifty-two patients (52 eyes) with diabetic ocular motor nerve paralysis were randomly divided into control group (n = 26) (26 eyes) and treatment group (n = 26). On the basis of the conventional treatment and improvement of microcirculation , The treatment group was given α-lipoic acid intramuscular injection, 1 times / day, 14 days after the two groups of eye position, eye movement, double vision examination and serum oxidative stress indicators detection. Results: The effective rates of the treatment group and the control group were 88.46% and 61.54%, respectively (P <0.05). The effective rates were 46.15% and 11.54% respectively (P <0.01). After treatment, the level of superoxide dismutase (SOD) increased and the level of malondialdehyde (MDA) decreased. Conclusion: Alpha lipoic acid has obvious therapeutic effect on diabetic ophthalmoplegia.