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肝细胞癌(HCC)是实体瘤中恶性度极高的一种癌。1984年日本肝癌研究小组报道,HCC的一年生存率,在手术切除病例为55%,在未手术切除病例仅为5%。尽管有些HCC生长缓慢,但还未获得鉴别其生物学行为的客观指标。有人认为在肿瘤生物学和功能方面,测定DNA含量比计数中期染色体数目更有意义,在受损害的不同器官中,测定DNA含量已用于鉴别诊断或估价预后。作者曾报道用细胞分光光度计检测早期胃癌和食管粘膜内及粘膜下癌DNA分析的结果。关于HCC的DNA含量与恶性程度之间的关系尚未见报道。本文研究HCC细胞核
Hepatocellular carcinoma (HCC) is a highly malignant cancer in solid tumors. In 1984, the Japanese HCC research team reported that the one-year survival rate of HCC was 55% in surgical resection and only 5% in unresected cases. Despite the slow growth of some HCCs, no objective indicators for identifying their biological behavior have been obtained. Some people think that in the aspect of tumor biology and function, the determination of DNA content is more meaningful than counting the number of metaphase chromosomes. In different damaged organs, the determination of DNA content has been used for differential diagnosis or evaluation of prognosis. The authors have reported using cell spectrophotometers to detect the results of DNA analysis of early gastric cancer and esophageal mucosal and submucosal cancers. The relationship between the DNA content of HCC and the degree of malignancy has not been reported. This article studies HCC cell nuclei