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催醒宁用于中麻术后催醒取得了良好效果,但它尚存在一定的缺点,特别是对心血管系统有一定的副作用。催醒安化学名为二甲胺基甲酸-间-(β-二甲胺基)乙氧基苯酯盐酸盐,系我组在1973年设计合成。经动物实验证明,本品的中枢毒蕈碱样作用与催醒宁相当,但烟碱样作用很弱,毒性小,对中麻催醒效果确切。济南部队88医院等中麻协作单位将催醒安用于中麻术后催醒300余例,证明其效果优于依色林和催醒宁,付作用少,安全可靠。催醒安的结构比较简单,易于合成,可用间苯二酚为原料,经醚化、酯化、成盐三步反应制得。现将合成方法作简要介绍。
Arousal Ning used for post-anesthesia wake up achieved good results, but it still has some shortcomings, especially on the cardiovascular system has some side effects. A reminder of the chemical known as dimethyl amino acid - m - (- dimethylamino) ethoxy phenyl ester hydrochloride, the Department of my group in 1973, design and synthesis. Animal experiments show that the central muscarinic effect of this product and rather reminder quite Ning, but nicotine-like effect is weak, toxicity is small, the effect of awakening in the exact. Jinan unit 88 hospitals and other anesthesia units will be reminded to use in the wake of anesthesia in the wake of more than 300 cases, that its effect is better than the shade and reminder rather Ning, pay less, safe and reliable. Awake Ann’s structure is relatively simple and easy synthesis, available resorcinol as raw material, the etherification, esterification, salt-derived three-step reaction. The synthetic method is now briefly introduced.