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目的：通过高原人血浆EPO测定，探索高原红细胞增多症（HAPC）的发病机理。方法：采用酶标法规定111例血浆EPO。结果：藏族健康者36例，EPO均值为6．13mlU／ml；汉族健康者36例，均值为10．69mlU／ml；藏族HAPC20例，均值为13．06mlU／ml；汉族HAOC19例均值为61．24mlU／ml。结果提示：汉族无论健康组还是HAPC病人组都高于藏族；且HAPC病人EPO含量高于健康者。结论：在高原低氧环境下，EPO增加可使RBC增多，从而引起HAPC，但这不是唯一的因素，有关调控机制正在进行深入研究。
Objective: To explore the pathogenesis of high altitude polycythemia (HAPC) by measuring plasma EPO in high altitude. Methods: 111 cases of plasma EPO were determined by ELISA. Results: Among 36 healthy Tibetan subjects, the mean EPO was 6.13mlU / ml; 36 healthy subjects were Han nationality, mean was 10.69mlU / ml; Tibetan HAPC was 20 cases, mean was 13.06mlU / ml; 24mlU / ml. The results suggest that: Han nationality group is higher than Tibetan or HAPC patient group; and HAPC patients EPO content is higher than healthy people. CONCLUSION: Under the condition of hypoxia in the plateau, the increase of EPO can increase the RBC and cause HAPC, but this is not the only factor. The relevant regulatory mechanisms are under further study.