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目的探讨乙型肝炎疫苗和乙型肝炎免疫球蛋白联合使用对乙型肝炎母婴传播的阻断效果。方法 305例中有230例新生儿出生后加强乙肝疫苗20μg同时注射同时注射乙肝免疫球蛋白100μg,而剩余75例只注射乙肝疫苗20μg。结果联合应用乙肝疫苗及乙肝免疫球蛋白230例婴儿中,有30例追踪失败,无下落。200例婴儿追踪至3岁上幼儿园前查乙肝五项,约141名幼儿有抗体,59名幼儿无抗体。而75例只注射乙肝疫苗幼儿有30例有抗体,45名无抗体。结论经过这种方法预防,所有的乙肝表面抗原阳性产妇可以哺乳,新生儿也可获得很好的预防效果。
Objective To investigate the blocking effect of combined use of hepatitis B vaccine and hepatitis B immunoglobulin on mother-to-infant transmission of hepatitis B virus. Methods Among 305 newborns, 230 newborns were boosted with 20 μg of hepatitis B vaccine and 100 μg of hepatitis B immunoglobulin simultaneously, while the remaining 75 cases received only 20 μg of hepatitis B vaccine. Results In the combined application of hepatitis B vaccine and hepatitis B immunoglobulin in 230 infants, 30 cases failed to follow-up without any drop. Two hundred babies were followed up to five items of hepatitis B before kindergarten of 3 years old. About 141 babies had antibodies and 59 babies had no antibody. And 75 cases of hepatitis B vaccine injection only 30 cases of antibodies, 45 no antibody. Conclusion After this method of prevention, all HBsAg positive mothers can breastfeed, newborns can also get a good preventive effect.