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应用超声心动图观察１３４例不同疾病患者，根据其左房内径、左室舒张末期容积、平均动脉压、平均周径缩短率及射血分数的不同，判断其前后负荷的大小及心肌收缩力的强弱。将观察对象分为５组，并分别选择年龄、心率匹配的健康人为对照组，发现前负荷变化主要影响舒张早期左室充盈，随前负荷增高，跨瓣驱动压上升，舒张早期充盈峰值流速（ＥＰＦＶ）加快，舒张早期流速积分（ＥＴＶＩ）及总舒张期流速积分（ＴＴＶＩ）加大。后负荷变化影响舒张早期及心房收缩期左室充盈。后负荷降低使ＥＴＶＩ加大，心房收缩期充盈峰值流速（ＡＰＦＶ）减慢，流通积分（ＡＴＶＩ）减小，Ａ／Ｅ比值及心房充盈分数（ＡＴＶＩ／ＴＴＶＩ）下降。心肌收缩力下降则使ＥＰＦＶ减慢，ＥＴＶＩ减小，代偿性ＡＰＦＶ加快及ＡＴＶＩ加大，Ａ／Ｅ及ＡＴＶＩ／ＴＴＶＩ增加，以维持心输出量。
According to the left atrium diameter, left ventricular end-diastolic volume, mean arterial pressure, the shortening rate of average circumferential diameter and the ejection fraction, 134 patients with different diseases were observed by echocardiography to determine the magnitude of anterior-posterior load and myocardial contractility Strong or weak. The subjects were divided into five groups, and the age and heart rate matched healthy people were selected as the control group. It was found that the changes of the former load mainly influenced the left ventricular filling during the early diastole. The pre-diastolic filling pressure increased with the increase of the former load, EPFV) accelerated, early diastolic velocity integral (ETVI) and total diastolic velocity integral (TTVI) increased. Postload changes affect early diastolic and atrial systolic left ventricular filling. Postload decreased ETVI, decreased APFV, reduced ATVI, and decreased A / E ratio and atrial filling fraction (ATVI / TTVI). Myocardial contractility decreased EPFV slowed, ETVI decreased, compensatory APFV accelerated and ATVI increased, A / E and ATVI / TTVI increased in order to maintain cardiac output.