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【目的】观察依帕司他联合单唾液酸四己糖神经节苷脂钠治疗糖尿病周围神经病变（DPN ）的效果。【方法】将76例DPN患者分为两组，观察组（ n ＝39）口服依帕司他每次50 mg ，3次/日，同时静脉滴注单唾液酸四己糖神经节苷脂钠100 mg/d ，连续治疗30 d。对照组（ n＝37），口服依帕司他每次50 mg ，3次/日，疗程同观察组。【结果】观察组总有效率（89．6％）高于对照组（50．6％），差异有统计学意义（P ＜0．05）。【结论】依帕司他联合单唾液酸四己糖神经节苷脂钠治疗DPN效果显著。“,”[Objective]To observe the efficacy of epalrestat combined with mono-sialic acid tetra hexose gangli-oside sodium for the treatment of diabetic peripheral neuropathy (DPN) .[Methods] Totally 76 patients with DPN were divided into two groups .The observation group( n =39) was given oral epalrestat 50mg/time for 3 times a day ,and simultaneously given intravenous mono-sialic acid tetra hexose ganglioside sodium 100mg/d for continu-ous 30 days .The control group( n =37) was given oral epalrestat 50mg/time for 3 times a day .The treatment course of control group was the same as that of observation group .[Results]The total effective rate of observation group(89 .6% ) was higher than that of control group (50 .6% )( P < 0 .05) .[Conclusion]Epalrestat combined with mono-sialic acid tetra hexose ganglioside sodium for the treatment of DPN has significant efficacy .