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采用立体定向技术，应用射频毁损深部位肿瘤。我们应用射频治疗仪在不同温度，不同时间下对蛋清、犬脑组织和人脑胶质细胞瘤进行毁损试验，并对毁损后的犬脑组织和人脑胶质细胞瘤进行光镜及电镜观察。发现４２℃、１２０Ｓ时可产生人脑胶质瘤的不可逆损伤，损伤区与未损伤区在光镜下观察界限非常明确，且随温度和时间的变化而变化。进行统计学分析，应用回归分析和目标归划方法，得到肿瘤的受损范围与射频毁损所采用的最适温度和时间的对应关系的数学模型。射频毁损灶的大小与温度的相关性强，与时间的相关性弱。据此研究短时间、高热毁损较为适宜，重要结构区、范围小的病灶可以适当延长时间（不宜超过３分钟）和用相对较低的温度加热，为射频的临床应用提供了科学依据
Using stereotactic technology, the application of radio frequency rupture deep tumor. We use radio frequency therapeutic apparatus at different temperatures and different times on egg white, canine brain tissue and human glioma rupture test, and after the damage of canine brain tissue and human glioma were observed by light microscopy and electron microscopy . It was found that 42 ℃, 120S can produce irreversible damage to human glioma, the damage zone and the undamaged zone in the light microscope to observe the boundary is very clear, and changes with temperature and time. Statistical analysis was carried out, and the mathematical model of the corresponding relationship between the damage extent of the tumor and the optimal temperature and time adopted by radio frequency rupture was obtained by regression analysis and target reduction method. The size of radio frequency rupture foci is highly correlated with temperature and weakly correlated with time. Therefore, the study of short-term, high heat damage is more appropriate, the important structural area, a small range of lesions can be properly extended (not more than 3 minutes) and with relatively low temperature heating, for the clinical application of RF provides a scientific basis