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目的探讨广东粤西沿海地区Graves病发病与尿碘的相关性以及正常成年人碘营养状况。方法收取2006年门诊及住院患者中初诊为Graves病(Graves’disease,GD)102例和正常对照组100例,应用砷铈催化分光光度法测定其尿碘含量和用免疫化学发光法测定外周血FT3,FT4,TSH,甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)。结果 GD组尿碘中位数为305.50μg/L,正常对照组尿碘中位数为263.51μg/L,两组比较差异有统计学意义(Z=-2.558,P=0.011);GD组中尿碘在300μg/L以上发生突眼占21%,高于其它各组(P<0.05),TPOAb和TGAb水平同样高于其它各组(χ2=9.567,P=0.023;χ2=8.414,P=0.038)。结论提示湛江沿海地区成人碘摄入量偏高;碘可能诱发GD的发生和加重GD突眼。
Objective To investigate the correlation between the incidence of Graves’ disease and urinary iodine and the iodine nutrition of normal adults in the coastal areas of western Guangdong. Methods A total of 102 outpatients and inpatients with Graves’ disease (GD) were enrolled in 2006 and 100 normal controls. Serum arsenic and cerium were used to determine the urinary iodine content and the levels of peripheral blood were measured by immunochemical chemiluminescence FT3, FT4, TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb). Results The median urinary iodine in GD group was 305.50μg / L, and the median urinary iodine in normal control group was 263.51μg / L, with significant difference between the two groups (Z = -2.558, P = 0.011). In GD group Urine iodine exceeded 300μg / L in more than 21%, higher than other groups (P <0.05), TPOAb and TGAb levels were also higher than other groups (χ2 = 9.567, P = 0.023; 0.038). Conclusions suggest that adult iodine intake in Zhanjiang coastal areas is high; iodine may induce the occurrence of GD and aggravate the exophthalmos.