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目的探讨2型糖尿病肾病患者颈动脉斑块与血清脂联素的关系。方法选择2型糖尿病肾病患者共120例,据GFR(据MDRD方程计算)分为3组:A组(40例):GFR>30ml/min/1.73m2;B组(40例):GFR≤30ml/min/1.73m2非透析组;C组(40例):透析组,已行透析治疗的患者。另选2型糖尿病无慢性并发症患者60例作对照即D组。入选者测血肌酐、尿素氮、血尿酸、空腹血糖、甘油三酯、低密度脂蛋白胆固醇、血浆白蛋白、血红蛋白、糖化血红蛋白、血钙、血磷、甲状旁腺激素、纤维蛋白原、24h尿蛋白总量、血清脂联素及颈总动脉内中膜厚度。结果 2型糖尿病肾病患者的颈动脉内中膜厚度和对照组相比显著增厚;2型糖尿病肾病患者血清脂联素水平和对照组相比显著升高;血清脂联素水平和颈动脉内中膜厚度呈正相关。结论 2型糖尿病肾病患者颈动脉斑块和血清脂联素有关(r=0.472)。
Objective To investigate the relationship between carotid plaque and serum adiponectin in type 2 diabetic patients with nephropathy. Methods A total of 120 patients with type 2 diabetic nephropathy were enrolled in this study. They were divided into three groups according to GFR (MDRD equation): group A (40 cases): GFR> 30ml / min / 1.73m2; group B /min/1.73m2 non-dialysis group; C group (40 cases): dialysis group, dialysis patients have been treated. Another type 2 diabetes without chronic complications in 60 patients as a control group D. Participants were measured serum creatinine, blood urea nitrogen, blood uric acid, fasting blood glucose, triglycerides, low density lipoprotein cholesterol, serum albumin, hemoglobin, glycosylated hemoglobin, serum calcium, phosphorus, parathyroid hormone, fibrinogen, 24h Total urinary protein, serum adiponectin and carotid intima-media thickness. Results In patients with type 2 diabetic nephropathy, the carotid intima-media thickness was significantly thicker than that in the control group. Serum adiponectin levels in patients with type 2 diabetic nephropathy were significantly higher than those in the control group. Serum levels of adiponectin and carotid artery Median thickness was positively correlated. Conclusion Carotid artery plaque is associated with serum adiponectin in patients with type 2 diabetic nephropathy (r = 0.472).