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目的观察甲亢患者的BMD改变及病程、TT3、年龄和性别对其改变的影响。方法用单光子骨密度仪测量了 12 9例未治甲亢患者桡骨BMD。结果甲亢组的桡骨BMD低于正常对照组 (P<0 0 1) ,BMD减低发生率为 2 4 80 %。多元线性回归分析表明 90例女性甲亢患者的桡骨BMD与病程及年龄呈负相关 ,而与TT3 无关 ;39例男性甲亢患者的桡骨BMD与病程呈负相关 ,而与TT3 和年龄无关。结论甲亢对骨质改变有重要影响 ,病程是造成甲亢患者BMD减低的首要因素 ,女性患者的BMD减低同时受年龄的影响。
Objective To investigate the changes of BMD, the course of disease, TT3, age and gender in hyperthyroidism patients. Methods Radial BMD was measured in 12 9 patients with unreasonable hyperthyroidism by single photon densitometry. Results The BMD of radius of hyperthyroidism group was lower than that of normal control group (P <0.01), and the incidence of BMD reduction was 2480%. Multivariate linear regression analysis showed that the BMD of radius in 90 female patients with Hyperthyroidism was negatively correlated with age and course of disease, but not with TT3. The BMD of radius in 39 male patients with Hyperthyroidism was negatively correlated with duration of disease, but not with TT3 and age. Conclusion Hyperthyroidism has an important effect on bone changes. The course of disease is the primary factor for reducing BMD in patients with hyperthyroidism. The reduction of BMD in female patients is also affected by the age.